Response of Caenorhabditis elegans during subsequent infections with Gram positive and Gram negative bacteria
نویسندگان
چکیده
Background The nematode Caenorhabditis elegans is one of the popular model hosts for the study of the evolutionarily conserved mechanism of microbial pathogenesis and innate immunity. C. elegans can be effectively used to study the dynamics of polymicrobial infections. Proteus mirabilis, an opportunistic pathogen, does not cause death in C. elegans. In this study the C. elegans was pre-infected with Staphylococcus aureus to make the C. elegans immunocompromised to study the effect of P. mirabilis in the host.
منابع مشابه
Pattern of antibiotic resistance in nosocomial infections with Gram-negative bacilli in ICU patients (Tehran, Iran) during the years 2012-2014
Background and Objective: Owing to the new patterns of antibiotic resistance, selection of the appropriate antibiotics for the treatment of nosocomial infections, especially gram-negative bacilli, has become a big challenge. Therefore, the aim of this study was to evaluate the antibiotic resistance of nosocomial infections with Gram-negative bacilli in Iran during the years 2012-2014. Material...
متن کاملInteractions with microbial pathogens.
A wide variety of bacterial pathogens, as well as several fungi, kill C. elegans or produce non-lethal disease symptoms. This allows the nematode to be used as a simple, tractable model host for infectious disease. Human pathogens that affect C. elegans include gram-negative bacteria of genera Burkholderia, Pseudomonas, Salmonella, Serratia and Yersinia; gram-positive bacteria Enterococcus, Sta...
متن کاملبررسی سطح اندوتوکسین خون بیماران همودیالیزی و مقایسه آن با کشت خون
Introduction: Presently, bacteremia is the principal cause of morbidity in patients undergoing hemodialysis. Gram-negative bacteria account for approximately 50 percent of documented infections. Endotoxins released during lysis of gram negative bacteremia result in inflammatory and defense response by the body and if not treated promptly result in septic shock and ultimately death of the patie...
متن کاملHydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes.
Caenorhabditis elegans is currently introduced as a new, facile, and cheap model organism to study the pathogenesis of gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella enterica serovar Typhimurium. The mechanisms of killing involve either diffusible exotoxins or infection-like processes. Recently, it was shown that also some gram-positive bacteria kill C. elegans, although t...
متن کاملPhytosynthesis of silver nanoparticles with the aqueous extract of portulaca oleracea and its antimicrobial and antioxidant effect against gram-positive and gram-negative bacteria
Background: Due to the importance of investigating nosocomial infections and drug resistance in bacteria causing these infections, the use of herbs can be very helpful in treatment. In the present study, the effect of silver nanoparticles obtained from portulaca oleracea extract on bacteria causing nosocomial infections and effective parameters in the synthesis of these nanoparticles were inves...
متن کامل